By Lena H. Sun
The Washington Post
Federal officials warned Tuesday that “nightmare bacteria” — including the deadly superbug that struck a National Institutes of Health facility two years ago — are increasingly resistant to even the strongest antibiotics, posing a growing threat to hospitals and nursing homes nationwide.
Thomas Frieden, director of the Centers for Disease Control and Prevention, said at a news conference, “It’s not often that our scientists come to me and say we have a very serious problem and we need to sound an alarm. But that’s exactly what we are doing today.”
He called on doctors, hospital leaders and health officials to work together to stop the spread of the infections. “Our strongest antibiotics don’t work and patients are left with potentially untreatable infections,” he said.
Although the bacteria, known as Carbapenem-Resistant Enterobacteriaceae, or CRE, haven’t spread to the wider community — like some other germs — they are more dangerous said Frieden, who described them as a “triple threat.”
First, the bacteria are resistant to all or nearly all antibiotics, even those of last resort, he said. Second, they kill up to half of patients who get bloodstream infections from them. And third, the bacteria can transfer their antibiotic resistance to other bacteria within the family, potentially making other bacteria untreatable as well.
For example, carbapenem-resistant Klebsiella, which caused the NIH outbreak, “can spread the genes that destroy our last antibiotics to other bacteria, such as E. coli, and make E. coli resistant to antibiotics also,” Frieden said.
E. coli is the most common cause of urinary tract infections in healthy people.
In 10 years, the percentage of Enterobacteriaceae resistant to antiobiotics increased almost fourfold, to 4.2 percent in 2011 from 1.2 percent in 2001, according to data reported to CDC. And the strain that caused the NIH outbreak has increased sevenfold in the past decade, according to a CDC report issued Tuesday.
During the first half of 2012, almost 200 hospitals and long-term acute-care facilities treated at least one patient infected with these bacteria. The CDC did not have statistics for fatalities.
Enterobacteriaceae are a family of more than 70 bacteria, including E. coli, that normally live in the digestive system. Over time, some of these bacteria have become resistant to a group of antibiotics known as carbapenems, often referred to as last-resort antibiotics. During the past decade, CDC tracked one type of CRE from a single health-care facility to facilities in at least 42 states, according to a CDC news release.
Only six states — Tennessee, Minnesota, Colorado, Wisconsin, Oregon and North Dakota — require hospitals and health-care facilities to report CRE infections to state health departments.
The NIH outbreak sickened 19 patients, including the woman who brought the germ with her when she was transferred to the Bethesda facility; 12 patients died. Seven of the deaths were directly attributed to an antibiotic-resistant strain of the bacterium Klebsiella pneumoniae.
When the outbreak erupted, the clinical center’s infection control staff scrambled, walling off infected patients and tearing out plumbing. They swabbed equipment, walls, railings and patients to track and contain the bacterium. Despite these extreme efforts, the outbreak still ticked along for more than a year as the hardy superbug lingered on hard surfaces — and inside patients, among the sickest of the sick.
The seven patients who died of bloodstream Klebsiella infections had immune systems weakened by cancer, anti-rejection drugs given after organ transplants, and genetic disorders.
Almost all CRE infections occur in patients receiving care for serious conditions in hospitals, long-term acute-care facilities (such as those providing wound care or ventilation) or nursing homes.
These patients often have catheters or ventilators, which can allow bacteria “to get deeply into a patient’s body,” Frieden said.
The germs themselves spread from person to person, often on the hands of doctors, nurses and other health-care professionals.
The CDC said the spread of the germs can be controlled with proper precautions and better practices. Standard infection control precautions include washing hands and dedicating staff, rooms and equipment to the care of patients with CRE. Prescribing antibiotics wisely can significantly reduce the problem.
Patients who are hospitalized can, and should, ask their doctors and nurses to wash their hands before touching them, the officials said. And patients should not always demand antibiotics for their illnesses.
“Not all fevers require antibiotics. The more we use antibiotics, the more we encourage the spread of antibiotic resistance,” Frieden said.
Toddler is youngest to ever get lab-made windpipe
CHICAGO — A 2-year-old girl born without a windpipe now has a new one grown from her own stem cells, the youngest patient in the world to benefit from the experimental treatment.
EPA methane report further divides fracking camps
PITTSBURGH — The Environmental Protection Agency has dramatically lowered its estimate of how much of a potent heat-trapping gas leaks during natural gas production, in a shift with major implications for a debate that has divided environmentalists: Does the recent boom in fracking help or hurt the fight against climate change?
NASA chief: Visiting an asteroid is all agency can afford
WASHINGTON - A NASA plan to send astronauts to an asteroid was met with skepticism Wednesday when NASA Chief Charlie Bolden presented the idea to top space officials in Congress - though their doubts may not be enough to sink the program.
At Navy Yard, ’living lab’ of energy efficiency
PHILADELPHIA - Building 661 at the Navy Yard was never a thing of beauty. Built in 1942, during the first months of U.S. involvement in World War II, the brick-and-concrete structure’s purpose was to house an indoor swimming pool, basketball courts, and offices, a function it pragmatically performed until the Philadelphia Naval Shipyard closed in 1995.
Expo seeks to inspire new generation of robot-builders
Robots that can transfer plastic rings. Robots that can toss Frisbees into targets. Robots that can climb, swim, dance, or make music. Robots that can clean up a nuclear plant after a Fukushima-style disaster, sparing human beings the risk of radiation poisoning.
UN official hopeful about 2015 climate talks
DUBAI, United Arab Emirates — Governments are more serious and the impact of climate change is more dramatic, improving chances of a groundbreaking global warming pact in 2015 in contrast with the failure of such an effort in 2009, the U.N. climate chief said Tuesday.
Whiz kids show their stuff at White House science fair
In his dark blue business suit, President Barack Obama climbed onto a bicycle anchored to the ground outside the White House. He pedaled in his polished dress shoes, generating electricity to run a water sanitation system built by a group of Florida teenagers.
How Rocking a Baby Is Like Holding a Kitten by the Neck
A human mother rocking a baby in her arms and a cat carrying her kitten by the scruff of its neck have the same physiological effect on both young animals and probably stem from the same maternal instinct to protect their young. That's the conclusion of a new study, which for the first time has compared the physiological impact of maternal carrying behaviors across species. The findings may lead to better parenting techniques for people and possibly to new ways to detect developmental disorders early in life.
'Living Fossil' Gets Its Genome Sequenced
The coelacanth isn't called a "living fossil" for nothing. The six-foot-long, nearly 200-pound fish was thought to have gone extinct 70 million years ago — until a fisherman caught one in 1938 — and the animal looks a lot like its fossil ancestors dating back 300 million years. Now, the first analysis of the coelacanth's genome reveals why the fish may have changed so little over the ages. It also may help explain how fish like it moved onto land long ago.
Ancient Mating Dance Offers Ranchers, Birds a Lifeline
BURWELL, Neb. — Under an indigo pre-dawn sky, as a frigid wind whipped across the plains, a half-dozen brown-and-white birds emerged from tufts of dry grass. They emitted a low cooing sound, akin to the hooting of an owl.
- More Science/Technology Headlines
- Toddler is youngest to ever get lab-made windpipe